Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your PRE SEED is a sperm friendly vaginal lubricant recommended for women who are trying to conceive but experience vaginal dryness during sexual intercourse. Most other lubricants either kill sperm or alter the morphology motility of Let's talk about lubricants and fertility. If you're TTC, the type of lube you use can either support or sabotage your chances of conceiving. Here's what research shows: All impact sperm in Do lubricants affect male fertility and sperm quality?